Peter Parker, now living on his own and trying to hold down a job, finds that super-heroing is not all it’s cut out to be. When one of his own heroes, Dr. Otto Octavius accidentally fuses an experimental harness of robotic tentacles to his spine, Peter must stop the now deranged scientist from killing Aunt May and destroying the city. And on top of that, his best friend Harry blames Spider-Man for his fathers death. It’s almost enough to make a guy quit being a web-slinging hero!
- Billboard, New York
- Joe’s Pizza, New York
- Busy Street, New York – Pizza Delivery
- Millennium Park, New York
- Onlooker and Jones Alley
- Crosswalk, New York – Park Intersection
- Daily Bugle Offices
- Columbia University
- Peter Parker House/Mary Jane Watson House, Queens
- Peter Parker Apartment
- Otto Octavius Incorporated
- Laundromat, New York
- Lyric Theater, Off Broadway
- Flower Stand, New York
- Moped Accident
- Police Chase, New York
- Webbed Police Car – Stopping Robbers
- Quick Change Alley, New York
- InterContinental New York Barclay
- Midtown Hospital, New York
- Establishing Shot, New York
- Abandoned Pier 56
- National Savings and Loan
- In-Universe: Nassau & John Streets
- City Hall Park – Lands with Aunt May
- Planetarium, New York
- Rainy Alley, New York
- CoSTUME NATIONAL, New York – Shoe Store
- Alley, New York – Throwing away costume
- Madison Square Park, New York
- Sidewalk, New York – Tripping
- Chinatown, New York
- Sidewalk, New York – Outside Lafayette News
- Sidewalk and Alleyway
- Cemetery, Queens
- Osborn Penthouse
- Apartment Fire, New York
- Rooftops, New York
- Ari’s Village Delicatessen – Cafe
- Westside Clock Tower, New York
- Train Fight
- Street Surfing
- Train Terminus
- Cargo Pier, New York
- Riverside Church, New York
- City Hall Park, New York
Spider-Man 2 was shot at Sony Studios Los Angeles, and the surrounding area, and in the New York area.