If I can make it there, I’ll make it anywhere.
Throughout the movies, shots of New York City are used as transitions and to help remind audiences where the film takes place. The establishing shot from the first film is in the financial district of Manhattan looking North. The major buildings here include: The Trump Building (left), 68 Wall St (trapezoidal), 70 Pine St (tower), and One Financial Square in the middle.
The establishing shot below was used just before Doc Ock discovered the abandoned pier where he set up his new lab. This is a flopped (l to r) shot of Pier 25 Hudson River Park, New York.
The final film of the trilogy has two establishing shots of New York. The first is at the end of the opening credits (which retell the story, somewhat, up to this point) and features the Brooklyn Bridge, looking into Manhattan.
The second shot of New York architecture is an aerial view of Midtown Manhattan looking East during sunrise, specifically focusing on the Met Life Tower at 1 Madison Ave.
(Spider-Man, 2002; Spider-Man 2, 2004; Spider-Man 3, 2007)