So, everyone, raise your glasses to Pete and Mariya, the Leitners.
The nuptials of the Leitners are interrupted by HYDRA agents testing out a bio-weapon, attempting to replicate the effects of the Obelisk.
The Rendezvous Room at the Los Angeles Biltmore Hotel, a famous location for films and television shows, was used as the setting for this wedding reception. The fact that it takes place in San Diego was confirmed in both the TV news footage Coulson was watching in his office and in the Agents of SHIELD Season Two Declassified book.
MAP
(Agents of SHIELD S02E05, 2014)
MCU: Location Scout 