We got three cars in pursuit.
After seeing his uncle dead, Peter takes off after the robber. He lands on top of a domed building and observes the car headed south on Lexington Ave, past the Hotel Roger Smith.
The domed building would be at approximately Lexington Ave and E 48th St, if it existed. It, along with much of Peter’s footage on the dome, was digitally created. The Hotel Roger Smith is a real location however, and is located at 501 Lexington Ave, in New York.
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(Spider-Man, 2002)