This place was originally built during Prohibition.
Daisy and May duck into a SHIELD safe house to avoid an explosive shot by HYDRA. Inside, they meet Mack and Burroughs, who take them back to the Playground.
This was a tough interior to find. The filmmakers did a great job of making it look like this is the same building that the Agents entered from the alleyway. However, that building and this one are entirely different shapes and orientations. A small detail was seen outside the door that helped to identify this location as the Golden Road Brewery on W San Fernando Road in the Atwater Village neighborhood. The inside looked like a brewery or other processing plant, and the signage outside helped confirm the location. The number “4” and a sign that looked to read “Plaza” (but was “Expendables Plus”) were found, just a few blocks north of where Daisy and May wandered the streets in this episode.






View of signage visible outside the door to the SHIELD safe house.
MAP
(Agents of SHIELD S04E19, 2017)